And if you haven't already, you should read Setting up the keyboard or gamepad so you can actually play the game. Lastly, make sure to read CD swapping for multiple-CD games.Otherwise, select the CUE sheet via File > Open ROM.If you added the game's folder, simply double-click on the game's CUE sheet to load it.So my directions in loading a game apply the same way: From this point you can load the PlayStation 1 game as you would like any other ROM.*If your PlayStation 1 game is currently in a ZIP, 7Z, or RAR file, it must be extracted. It would look something like this (the icons would look different): Mednafen can only play ISOs that are in BIN/CUE or ISO/CUE format. Before we load your game I need to point out an important detail.Place the BIOS file(s) in Mednafen's main directory, as shown here.For example, if your NA BIOS is named “ SCPH-5501.BIN”, you must rename it to “ scph5501.bin”. You must name the BIOS exactly as shown here.scph5502.bin - required for Europe-region games.scph5501.bin - required for North America/US-region games.scph5500.bin - required for Japan-region games.I mean, you don't need all three, you just need the BIOS for the region you want to play. Mednafen specifically requires the following BIOS files.You can download it from my emulators page. Anyway, here's how to load PlayStation 1 games with Mednafen:

Scph 5501 us playstation bios